Added 9 October 2026 mainframe /ˈmeɪnˌfɹeɪm/ noun Categories: ThingsRare Words noun ! Definition from WordNet 3.1, Princeton University. Pronunciation from Wiktionary, via Kaikki.org. More about mainframe at Wordnik → Where our words come from → A large digital computer serving 100-400 users and occupying a special air-conditioned room. (computer science) the part of a computer (a microprocessor chip) that does most of the data processing. the CPU and the memory form the central part of a computer to which the peripherals are attached Origin From main + frame. From Wiktionary, via Kaikki.org (CC BY-SA) Related Words: processorcpuservercomputerdistancecentralhostsystemconsole Back to today's word