Added 10 October 2026 depressant /dɪˈpɹɛsənt/ noun Categories: ThingsRare Words noun ! Definition from Wiktionary (CC BY-SA). Pronunciation from Wiktionary, via Kaikki.org. More about depressant at Wordnik → Where our words come from → A pharmacological substance which decreases neuronal or physiological activity. Alcohol acts first as a stimulant and then as a depressant. An agent that inhibits the flotation of a mineral or minerals. adjective Reducing functional or nervous activity. Related Words: ataraxicsedativeataractictranquilizingnarcoticsomniferoussoporificsoporiferoussomnificdownerrelaxantnarcotizing Back to today's word